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Research group “Bacterial multidrug resistance”
Winfried V. Kern
Principal Investigator, Head, Division of Infectious Diseases
1976-1982
Study of medicine in Bordeaux, Erlangen-Nuremberg, and Heidelberg, Germany
1983-1984
Resident, Institute of Tropical Hygiene and Public Health, University of Heidelberg, Germany
1985-1987
Resident, Department of Medicine, University Hospital Ulm, Germany
1988/1989
Research fellow, Hygiene-Institute, Tübingen, Germany, Brown University, Providence (RI), and University of California at San Francisco (CA), USA
1989-1994
Clinical fellow, Infectious and Tropical Diseases and Immunology, University Hospital Ulm, Germany
1994
Board certification in Internal Medicine, 1995 Assistant Professor of Medicine
1995-2001
Attending physician, Infectious and Tropical Diseases and Immunology, University Hospital Ulm, Germany
since 2002
Professor of Internal Medicine and Infectious Diseases, Albert-Ludwigs-University, and Head, Division of Infectious Diseases, University Hospital Freiburg, Germany
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Bacterial multidrug resistance has been an emerging clinical problem in many parts of the world. The mechanisms are diverse and include acquisition of genes involved in drug inactivation or bypass, mutations in multiple target genes, but also in non-target regulatory genes. Mutations in non-target genes usually lead to non-specific resistance, affect several drug classes and provide low-level drug resistance sufficient to allow bacterial survival and acquisition or development of secondary resistance genes/mutations. The major topics of our research are mechanisms and inhibition of altered drug transport and drug efflux in bacteria. We are also involved in epidemiological studies examining the clinical relevance and burden of bacterial multidrug resistance, the efficacy of old and new drugs in this situation, and the impact of so-called ecological studies with drug-use interventions on bacterial resistance. |
Contact
Prof. Dr. Winfried Kern
Division of Infectious Diseases,
Department of Medicine
University of Freiburg - Medical Center
Hugstetter Straße 55
79106 Freiburg
Tel: 0761 - 270-18190 (Secretary)
Fax: 0761 - 270-18200
E-mail: winfried.kern@uniklinik-freiburg.de
